Toxicologic Pathology: A Primer 1st Edition

700 1,600 

There has been an enormous growth of interest in the field of toxicologic pathology and particularly on its impact on nonclinical safety assessment in global drug development and in the environment. Toxicologic pathologists play an important role in detecting test article-related adverse effects by characterizing morphologic changes in animal tissues and/or body fluids under prescribed study conditions or less clearly defined conditions in the environment and in the interpretation of these findings relative to human risk. In fact, pathology evaluation is often the single most important decision-making factor in nonclinical safety assessments as 80% of drug candidate attrition has been attributed to pathology findings in toxicity studies. There are currently no primers or basic overviews covering the field of toxicologic pathology, whereas there are at least several basic books that cover the sister field of toxicology.

Toxicologic Pathology: A Primer is a practical, easy-to-use reference designed to contain core information provided by board-certified veterinary pathologists, all experts in the field. The Primer contains the basic, underlying principles of toxicologic pathology at the introductory level; thus it will be valuable to the veterinary pathology student who may be considering a career in the field as well as a companion to the seasoned toxicologic pathologist who wants a succinct refresher. The Primer is arranged as chapters presenting each major organ system preceded by an overview chapter covering the field of toxicologic pathology followed by a “concept” chapter describing the role of toxicologic pathology in drug development. Photomicrographs and illustrations provide visual context.

The organ system chapters provide histopathologic descriptions of lesions observed in toxicity studies of test articles in drug development and testing of chemicals that may negatively impact the environment. Each organ system chapter provides additional information related to a particular lesion to aid the reader in better understanding its toxicologic significance relative to human risk.

Each organ system chapter contains:

  • A brief introduction
  • A succinct description of the anatomy and physiology of the system
  • Descriptions of the most important pathological lesions
  • Differential diagnoses
  • Biological consequences, pathogenesis, and/or mechanism of lesion formation
  • Associated clinical pathology correlates

Nonclinical safety scientists such as study directors, non-pathology-oriented contributing scientists such as senior toxicology report reviewers, scientific management of Contract Research Organizations (CROs), and students should find the Primer useful in helping them understand the fundamentals of toxicologic pathology.

 

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Description

Toxicologic Pathology: A Primer 1st Edition

By Gregory Argentieri (Illustrator), Pritam S. Sahota (Editor), Robert H. Spaet (Editor), Zbigniew W. Wojcinski (Editor)
  • Content Overview:
    • Introduction to the field of toxicologic pathology.
    • Organ system chapters:
      • Each chapter covers a major organ system with:
        • Brief introduction and description of anatomy/physiology.
        • Histopathologic descriptions of lesions in toxicity studies.
        • Differential diagnoses and biological consequences.
        • Pathogenesis and mechanisms of lesion formation.
        • Associated clinical pathology correlates.
    • Concept chapter on the role of toxicologic pathology in drug development.
  • Visual Aids:
    • Includes photomicrographs and illustrations for visual context.
  • Core Purpose:
    • Provides core, introductory knowledge on toxicologic pathology.
    • Serves as a practical reference for both students and experienced professionals.
Toxicologic Pathology: A Primer 1st Edition Now Available at Gangaram Jinnah Medical Bookshop For home delivery and Cash on delivery to all over Pakistan.
Buy online Medical books  at Gangaram Jinnah Medical Books Shop for home delivery and Cash on delivery to all over Pakistan. All kind of medical books are available.

Additional information

Quality

Black & white, Colour Matt Finish

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