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    Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems. - Provides comprehensive overview of the potential role of polymeric systems in drug delivery - Explores the design, synthesis, and application of different smart material-based delivery systems - Includes fundamental and clinical applications
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    STATISTICAL THINKING FOR NON-STATISTICIANS IN DRUG REGULATIONStatistical methods in the pharmaceutical industry are accepted as a key element in the design and analysis of clinical studies. Increasingly, the medical and scientific community are aligning with the regulatory authorities and recognizing that correct statistical methodology is essential as the basis for valid conclusions. In order for those correct and robust methods to be successfully employed there needs to be effective communication across disciplines at all stages of the planning, conducting, analyzing and reporting of clinical studies associated with the development and evaluation of new drugs and devices.Statistical Thinking for Non-Statisticians in Drug Regulation provides a comprehensive in-depth guide to statistical methodology for pharmaceutical industry professionals, including physicians, investigators, medical science liaisons, clinical research scientists, medical writers, regulatory personnel, statistical programmers, senior data managers and those working in pharmacovigilance. The author’s years of experience and up-to-date familiarity with pharmaceutical regulations and statistical practice within the wider clinical community make this an essential guide for the those working in and with the industry.The third edition of Statistical Thinking for Non-Statisticians in Drug Regulation includes:
    • A detailed new chapter on Estimado in line with the 2019 Addendum to ICH E9
    • Major new sections on topics including Combining Hierarchical Testing and Alpha Adjustment, Biosimilars, Restricted Mean Survival Time, Composite Endpoints and Cumulative Incidence Functions, Adjusting for Cross-Over in Oncology, Inverse Propensity Score Weighting, and Network Meta-Analysis
    • Updated coverage of many existing topics to reflect new and revised guidance from regulatory authorities and author experience
    Statistical Thinking for Non-Statisticians in Drug Regulation is a valuable guide for pharmaceutical and medical device industry professionals, as well as statisticians joining the pharmaceutical industry and students and teachers of drug development.
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    Symptoms in the Pharmacy: A Guide to the Management of Common Illnesses

    by Martin Duerden (Author), Alison Blenkinsopp (Author), John Blenkinsopp (Author)

    A Thorough Guidebook for Assessing and Managing Common Symptoms and Illnesses Seen in the Pharmacy

    Pharmacies, and pharmacists, are often the first source for information and advice used by a patient when health problems arise. This book supports pharmacists to recognize symptoms, advise with confidence, and recommend appropriate treatment or referral, while also providing a comprehensive digest of common conditions ideal for both practical use and reference.

    Informed by the experiences and expertise of seasoned pharmacists and GPs, each chapter in the book provides pharmacists and their staff working in the community with a decision-making framework along with suggestions on “when to refer” contained within summary boxes. A unique feature of the book is that case studies are provided throughout, in which pharmacists, doctors, nurses and patients themselves describe assessment and treatment of a wide range of common problems.

    This 9th edition of the book also includes:

    Consideration of conducting pharmacy consultations remotely as well as in person in the pharmacy New content on COVID-19 and Long-COVID in pharmacy practice Information about medicines recently reclassified for OTC supply Expanded content on women’s health including information on desogestrel, menopause and incontinence Broadening of the insomnia chapter to include consideration of mental health problems Increased content on non-drug treatment options and their supporting evidence A summary of evidence sources at the end of each chapter Decision-making support for unique cases which involve ethical dilemmas Practicing and Foundation trainee pharmacists, as well as undergraduate pharmacy students and other healthcare professionals, will find Symptoms in the Pharmacy: A Guide to the Management of Common Illnesses invaluable when dealing with both common and obscure symptoms and illnesses.

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    This reference book discusses the role of synbiotics in a wide range of disease states, including cardiovascular, reproductive, metabolic, neurodegenerative, gastrointestinal, thrombotic, skin, and inflammatory disorders. It reviews the functions of probiotics in the diagnosis, prevention, or treatment of various disease states. The book further covers improving the targeting efficiency of synbiotics through advanced drug delivery systems such as nanoparticles, microparticles, liposomes, microemulsion, solid lipid nanoparticles, and nano lipid carriers. The chapter addresses the implications of oral and topical delivery of synbiotics in different diseases and presents the safety assessment of synbiotics and clinical trials associated with synbiotics containing drug delivery systems for the treatment of diseases. The book also explores the synergistic welfare of synbiotics nutraceuticals in various conditions such as chronic respiratory diseases, gut health, and neurological functions and examines the toxicological profile, and regulatory aspects of nutraceutical supplements. As such, this book is a valuable resource for academics, research and industry professionals working in Pharmaceutical Sciences, Food Biotechnology, Immunology, and Health Sciences.​
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    Tailor-Made Polysaccharides in Drug Delivery provides extensive details on all the vital precepts, basics and fundamental aspects of tailored polysaccharides in the pharmaceutical and biotechnological industry for understanding and developing high quality products. The book offers a comprehensive resource to understand the potential of the materials in forming new drug delivery methods. It will be useful to pharmaceutical scientists, chemical engineers, and regulatory scientists and students actively involved in pharmaceutical product and process development of tailored-made polysaccharides in drug delivery applications. The utilization of natural polymeric excipients in numerous healthcare applications demand the replacement of the synthetic polymers with the natural ones due to their biocompatibility, biodegradability, economic extraction and readily availability. The reality behind the rise in importance of these natural materials is that these sources are renewable if grown in a sustainable means and they can tender incessant supply of raw materials. Amongst these natural polymers, polysaccharides are considered as excellent excipients because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of polysaccharides in drug delivery. - Provides methodologies for the design, development and selection of tailor-made, natural polysaccharides in drug delivery for particular therapeutic applications - Includes illustrations that demonstrate the mechanism of biological interaction of tailor-made polysaccharides - Discusses the regulatory aspects and demonstrates the clinical efficacy of tailor-made polysaccharides
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    Targeted Drug DeliveryNovel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugsTargeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting small molecules as well as peptide and macromolecular drugs, from prodrugs to drug conjugates to drug carriers and devices, helping readers to stay up to date on the latest developments in the field.The following key topics are addressed:
    • Antibody conjugates, prodrugs, and suicide gene therapeutics
    • Protac technology for selectively degrading target proteins
    • Delivery of nucleic acid drugs
    • Novel drug carriers, such as liposomes, vesicles, and nanoparticles
    • Unmet medical needs for which there is a large market potential, such as viral infections and cancer
    For chemists, pharmacologists, and professionals in the wider pharmaceutical industry, Targeted Drug Delivery is a comprehensive guide on how to solve the greatest challenge in treating many diseases: delivering a pharmaceutically active substance to the target tissue in the body.
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    This book presents information about the use of technology to support the prevention and management of drug safety issues: pharmacovigilance (PV), medication errors, drug-related problems (DRPs), counterfeit medicines and other drug safety issues. Adapting new technologies/information technologies, mobile technologies and social media has contributed effectively to safety practices for medications, with this book providing comprehensive information as a guide to its challenges and potential.Technology for Drug Safety provides practicing and trainee pharmacists, pharmacy technicians, pharmacy educators, researchers, public health policy makers, healthcare professionals and medical educators with vital information about the impact of technology on drug safety-related issues. It describes the current status of the practice, the challenges in the field and recommendations for the effective use of technology in drug safety practice including clinical trials and drug development, PV, detection of adverse drug reactions, reporting and management, medication errors detection, reporting and management, DRPs, counterfeit and substandard medications, and other safety issues.
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    Currently, there are no textbooks on drug product manufacturing technology transfer that incorporate the latest regulatory expectations. Recent guidance from regulatory bodies such as the US FDA, EMEA, WHO, and PIC/S has adopted the ICH Lifecycle approach harmonizing concepts across regulatory guidance. This allows organizations to align their technology transfer activities for all regulated markets. However, there is a need for consensus and direction in approaching technology transfer, particularly in understanding how to manage the scale-up effects to ensure regulatory compliance. This textbook offers technology transfer solutions and guidance to the pharmaceutical industry. The chapters provide a systematic understanding of applying the technology transfer concepts in pharmaceutical manufacturing, promoting standardization within the industry. Since Stage 1b is not specified in detail within the regulations, pharmaceutical organizations are left to determine the requirements of the stage. The need to justify the methodologies and utilization of sound science makes it more demanding. The textbook’s authors provide innovative solutions for technology transfer challenges, making it a comprehensive reference document. The approaches can be applied to both small-molecule and large-molecule drug product manufacturing segments, addressing the unmet needs of the industry.
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    The American Pipe Dream examines the many iterations of addiction as it was performed over the first half of the twentieth century, working from a massive archive of previously ignored material. Because the stage-addict became the primary way the U.S. public learned about addiction and drug use, Shulman argues that performance was essential in creating the addict in America’s cultural imagination. He demonstrates how modern-day perceptions of addiction and of the addict emerge from a complex history of accumulation and revision that spanned the Progressive Era, the Roaring Twenties, and the Great Depression.Chapters look at how theatre, film, and popular culture linked the Chinese immigrant and opium smoking; the early attacks on doctors for their part in the creation of addicts; the legislation of addiction as a criminal condition; the comic portrayals of addiction; the intersection of Black, jazz, and drug cultures through cabaret performance; and the linkage between narcotic inebriation and artistic inspiration. The American Pipe Dream creates active connections between these case studies, demonstrating how this history has influenced our contemporary understanding, treatment, and legislation of drug use and addiction.
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    The Apha Complete Review for the FPGEE 2nd Edition

    by Bradley A. Boucher (Author)

    The FPGEE (Foreign Pharmacy Graduate Equivalency Examination(R)) is the tallest hurdle for graduates of foreign pharmacy schools who wish to practice in the United States. With a pass rate that is under 60%, the FPGEE is a daunting 51/2 hour, 250-question exam that tests a wide range of knowledge in four major areas of pharmacy education: - Basic biomedical sciences (21%) - Pharmaceutical sciences (29%) - Social/behavioral/administrative pharmacy sciences (15%) - Clinical sciences (35%) Preparing for the FPGEE by reviewing all the material from each of your pharmacy school courses can be overwhelming. A far better approach is to study only the information most relevant to the exam, with the key points summarized in abbreviated bullet format. That's exactly what The APhA Complete Review for the FPGEE, 2nd Edition contains. Completely revised an updated, the second edition of The APhA Complete Review for the FPGEE is a one-stop compilation of pharmacy knowledge and serves as a premier resource for successfully passing the FPGEE on your journey being eligible to take the NAPLEX and MPJE exams, and becoming a licensed pharmacist in the U.S. Key Features - More than 700 review questions: All 30 chapters end with approximately 20 practice exam questions and answers, plus explanations that reinforce key learning points. - Key Points section: A Key Points section summarizes the contents of each chapter in abbreviated bullet format. - Test-taking tips: Peter A. Chyka offers invaluable advice on studying for and taking the FPGEE. NEW TO THE SECOND EDITION: - All chapters have been completely revised and updated. - New questions enhance and expand the scope of exam preparation. - Study Guide Checklist and additional resources in each chapter supplement and reinforce the material. - New chapters cover Fundamentals of Pharmacy Practice; Clinical Pathophysiology; Toxicology; Health Promotion, Prevention, and Population Health; Clinical Pharmacology and Therapeutic Decision Making; Economic and Humanistic Outcomes of Health Care Delivery; and Clinical Pharmacogenomics among other topics. Reference materials include: ASCVD Risk Assessment Hypertension Management Oral & Injectable Anticoagulants Diabetes Treatment Asthma & COPD Guidelines Antibiotic Dosing Special Populations Topics Immunization Schedules Helpful Equations Normal Lab Values Creatinine Clearance Opioid & Steroid Conversions Pharmacists' Patient Care Process Significant Drug Interactions Drug Withdrawal Nutrition

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    NOTE THAT THIS IS THE COMPLETE AND FINAL VERSION OF THE DRUG USERS BIBLE.People are dying because of ignorance. They are dying because unremitting propaganda is denying them vital safety information. They are dying because legislators and the media are censoring the science, and are ruthlessly pushing an ideological agenda instead. They are dying because the first casualty of war is truth, and the war on drugs is no different. This book makes a significant contribution in confronting this harrowing and tragic narrative.Over a 12 year period the author of this book self-administered over 180 psychoactive substances; both chemicals and plants. For each he recorded the life-sensitive safety data, including the anticipated onset times, the common threshold doses, the routes of administration, and the expected duration of the experience.In addition, for every compound he also produced a trip report, detailing the qualitative experience itself. This delivered another invaluable insight, enabling, for example, an objective assessment of the extent of any loss of judgement and self-control.This is a substantial body of work, embracing a wealth of direct support material, including addiction/overdose advice, relative harm tables, and legal briefings. Its contents also extend to cover aspects such as drug tourism, psychedelic exploration and drug related culture. It is crammed with detailed reference data, and even includes its own drug dictionary.The Drug Users Bible is a unique and unprecedented volume of encyclopedic research, embracing the full extent of the drug scape. Its objective is to provide, without fear or compromise, core and critical information to support the health, welfare and well-being of the 250 million people in the world who use drugs.The book itself is lavishly illustrated with hundreds of photographs, taken by the author himself.THE TEN COMMANDMENTS The first section comprises a comprehensive introduction to crucial drug concepts and practices. This, in itself, is indispensable prior-reading for anyone who chooses to use a psychoactive substance.It contains, for example, a detailed risk mitigation procedure: 'The 10 Commandments of Safer Drug Use'. This presents a generic set of easily understood steps to aid personal safety, inclusive of an illustrated explanation of how to identity test the substances themselves.THE PSYCHOACTIVE DRUGS The full gamut of psychoactive chemicals and botanicals is meticulously covered. Well known examples include heroin, cannabis, xanax, kratom, cocaine, DMT, methamphetamine, ketamine, LSD, ayahuasca, alcohol, and MDMA. Lesser known examples include 4-ho-met, calea, ephenidine, mad honey, mapacho, a-PHP, and Yohimbe.The scope also extends well beyond the most common categories, of psychedelics, stimulants, depressants and dissociates. Included, for example, are dream herbs and nootropics. The investigation of psychoactivity was unbounded and unfettered.THE WORLDSCAPE Drug use does not occur in a vacuum, so the final section considers the wider context, with in-depth examination of everything from travel to the horrors of the war on drugs. Facts, science and genuine statistics replace the myths, fabrications and propaganda of the prevailing social order, again with welfare and safety emphasized.EDUCATION SAVES LIVES Education underpins harm reduction, and is the primary driver throughout. Indeed, personal safety is the first and last message, and guides the entire narrative. This is a book for drug users and their families. It is a book which will help to avert tragedy. It is a book which will save lives.
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    The final fix for alcohol and drug addiction: AVRT, addictive voice recognition technique

    By Jack Trimpey (Author)

    • Overview: Introduces the Addictive Voice Recognition Technique (AVRT) as a method for overcoming alcohol and drug addiction.
    • Key Focus: Teaches individuals to recognize and silence the "addictive voice" that encourages substance use, promoting self-control and independence in addiction recovery.
    • Approach: Offers a practical, self-empowerment-based solution to addiction without reliance on external support systems or traditional recovery programs.
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    Drugs and their illicit use have long fascinated writers and the public at large. Informed by new interdisciplinary perspectives, a growing number of academically trained historians are now approaching drugs as a wide-open topic for serious research. This Handbook of Global Drug History is the first major attempt by historians of drugs to take stock of the recent progress and directions of this field, utilizing both a global scope and long-term historical perspective. Thirty-five original essays simultaneously survey what is known historically about drugs across the world (in Europe, the Americas, Asia, and Africa) as well as illustrating their historical interconnections.The use of drugs in human culture goes back millennia with as many unique histories as cultures in which drugs were used. In the early modern world, human relationships with drugs changed, and drugs connected societies through transnational trade. In the nineteenth century, these diverse histories converge in defining the modern “pariah drugs” (among them alcohol, opium, and indigenous hallucinogens) and paved the way for the dramatic twentieth-century rise of both illicit drugs (such as cannabis, heroin, and cocaine) and global prohibitions. Now, in the twenty-first century, we see emerging possibilities for rethinking the global social, health, and policy approaches to drug trafficking and use.
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    In this Handbook, philosophers from around the world address the metaphysics, epistemology, and value of psychoactive (mind-altering) drug use.  In so doing, they attempt to answer questions such as: What does the fact of drug-induced mind-altering experiences tell us about natures of the mind, free will, and God?  What does it tell us about what, and how, we can know?  Are drug-induced mind-altering experiences valuable, morally, aesthetically, or otherwise?  Is the acquisition of drug-induced mind-altering experiences ever immoral?  Should the acquisition of drug-induced mind-altering experiences ever be legally prohibited?   The Handbook gives an overview of the current research, and sets the stage for future directions in philosophical thought relating to psychoactive drug use.
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    This handbook provides a comprehensive overview of drug-related death bereavement to increase understanding and help direct scientific research, with contributions from across the globe.It is the first comprehensive, cross-cultural, multidisciplinary review of research on drug-related death (DRD)bereavement. Chapters cover the impact of DRD at individual, family, cultural, and societal levels, and topics include working with, and social support for, families following drug-related loss, understanding grief processes of individuals, drug policy, and the importance of cultural contexts. The book also elaborates on methodological issues when researching DRD.This handbook will increase understanding of DRD bereavement and contribute to support for DRD bereaved persons and those who care for them professionally and personally. It is essential reading for professionals and academics in the field as well as anyone affected by DRD.
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    • Overview: Provides an alternative to traditional twelve-step programs for overcoming alcohol and drug dependence.
    • Key Focus: Teaches how to identify the impulse to use intoxicants, develop self-control, value sobriety, and replace addiction with self-supportive behaviors.
    • Approach: Focuses on personal empowerment and rational self-recovery without the reliance on group therapy or higher powers.
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    The WHO AWaRe (Access, Watch, Reserve) antibiotic book

    By World Health Organization

    Antimicrobial resistance (AMR) is a threat to global health and development and it contributes to millions of deaths worldwide each year. Inappropriate use and overuse of antibiotics are driving an increase in AMR and have a detrimental impact on the effectiveness of these critical medicines. Through the Global Action Plan on AMR, WHO is working to improve the surveillance of antimicrobial resistance and reduce inappropriate antibiotic consumption.

    There is a recognized need for high-quality resources to improve antibiotic prescribing globally. To address this need, a pragmatic approach was taken by WHO to develop actionable guidance for empiric antibiotic use.

    The WHO AWaRe (Access, Watch, Reserve) antibiotic book provides concise, evidence-based guidance on the choice of antibiotic, dose, route of administration, and duration of treatment for more than 30 of the most common clinical infections in children and adults in both primary health care and hospital settings. The information included in the book supports the recommendations for antibiotics listed on the WHO Model Lists of Essential Medicines and Essential Medicines Children and the WHO AWaRe classification of antibiotics.

    The WHO AWaRe antibiotic book is accompanied by summary infographics for each infection for both adults and children that provide a quick-reference guide for health care workers at the point of care.

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    Triple negative breast cancers (TNBC) are a biologically aggressive form of breast cancer and constitute approximately 10-15% of all breast cancer patients. Distant metastasis, lack of clinically targeted therapies and prognostic markers, makes the disease difficult to treat. Till now not much work has been carried out on this deadly disease. This book provides an overview of TNBC etiology, its treatment strategies and prognostic markers to identify the outcome of standard therapies. Signaling pathways namely cell proliferation, angiogenesis, invasion and metastasis, apoptosis, autophagy and others involved in complicating the disease have been described in the chapters to convey an understanding about the disease mechanisms. All the possible drugs either in pre-clinical or clinical stages have also been mentioned with data that depicts their efficiency in targeting altered genes. The book also introduces the reader to herbal medicine exhibiting high potency to target TNBC, their synthetic analogs used during chemotherapy and their ability to fight against chemo resistance. The concept of Phyto nanotechnology has also been discussed. The book helps create awareness among a broad range of readers about TNBC. It points to prioritizing the upgradation of health care facilities and re-designing future treatment strategies to provide maximum benefit to breast cancer patients.
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    The book reviews the recent research advances and their outcomes in the areas of structural biology, bioinformatics, phytochemistry and drug discovery. Chapters in the book cover multidisciplinary research to understand the molecular mechanisms involved in protein-protein/ligand interactions. It employs an integrative approach to identify the therapeutic targets for HIV, and cancer, pathogen and viral infection pathways and the identification of their potential drug candidates. The book also provides examples of computational molecular dynamics simulations to understand the conformational changes in the molecules. Some chapters are focused on exploring potent bioactive compounds from natural sources. This book can serve as a single source that covers several interdisciplinary research fields which will be beneficial to Researchers and students in postgraduate studies.
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    Topical and transdermal drug delivery systems (TDDs) have several advantages over traditional drug delivery methods, as they can be less invasive, more sanitary, more cost-effective, and may result in better patient compliance. TDDs play a significant role in therapeutics with a variety of preparations and approaches designed by expert formulation scientists. This volume integrates a wide variety of case studies, research, and theories to reveal their diversity and capture the novel approaches of transdermal and topical drug delivery employed by developers and content experts in the field. It provides an abundance of important information and state-of-the-art research on topical and transdermal drug delivery systems and addresses the basics of drug delivery systems, strategies to enhance permeation across membranes, and formulation and evaluation of diverse dosage forms.The volume presents an evaluation of the pros and cons of conventional drug delivery systems against TDDs and discusses the nuances of micro- and nano-systems in TDDs. The extraordinary packages of nano systems (vesicular systems, polymeric nanoparticles, nanoemulsion and dendrimers) are broadly discussed, and their applications are reviewed through a transdermal route.The book looks at TDDs and the main nanoparticles used in skin diseases and lesions of the aging, such as psoriasis, vitiligo, cancer, lesions of the aging and others. Chapters also discuss polymeric micelles in topical and transdermal delivery; microneedles; emulsion, nanoemulsion and microemulsion; TDDs in pulmonary drug delivery systems; nanoencapsulated nasal drug delivery systems; skin sensitivity and irritation testing for transposing transdermal drug delivery systems; and regulatory aspects of drug development for dermal products.Topical and Transdermal Drug Delivery Systems: Applications and Prospects will be a valuable resource for pharmaceutical scientists and researchers, industry professionals, and academicians and students of the pharmaceutical and biomedical sciences.
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