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    Best Young Woman Job Book: A Memoir

    Price range: 550₨ through 1,200₨
    Emma Healey just wants to be a writer, but that’s more a journey than a job, and the journey isn’t free. As a teenager, she begins her adventures in precarious employment when introduced by her actor/playwright mother to the role of “standardized patient,” performing illness as a living training dummy for medical students. In university, she joins a creative writing program, cultivating a poet’s interest in language while learning lessons about the literary world that have more to do with survival than art. Through her twenties, she writes software manuals for the world’s leading producer of online pornography, masters search engine optimization for a marketing firm run out of a bedroom by two Phish-loving brothers, narrowly escapes death as a research assistant for a television drama, and works the night shift captioning daytime TV. Along the way, as she navigates dating apps, tumultuous relationships, and the evolution of a voice that she is slowly learning to trust, she begins writing personal essays for money—and finds herself embroiled in a content economy that blurs the boundaries between day job and making art even further. Through the stories of several very odd jobs, each related to—but also achingly far from—the job she really wants, poet and essayist Emma Healey creates a unique snapshot of the gig economy that is also a timeless meditation on identity, value, and language. For a writer trying to pay the bills, life can be a work in progress.
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    Carbon-Based Nanocarriers for Drug Delivery 1st Edition

    Price range: 550₨ through 1,250₨
    Carbon-Based Nanocarriers for Drug Delivery enlists the latitudes and advancements in the synthesis processes, functionalization, and applications of carbon-based nanomaterials (CBNs) in targeted drug delivery systems (DDSs). It covers the applicability and suitability of CBNs as nanocarriers for efficient drug delivery application via elucidating the recent advancements in CBNs, their functionalized and innovative derivatives, and the relevant case studies. The book explores the necessity, efficacy, toxicological aspects, and challenges for the application of CBN in targeted DDSs. Some of the features of this book are provided as follows:
    • Provides elaborative description on significance and adaptability of carbon-based nanomaterial in targeted drug delivery for wide ranges of therapeutics
    • Delivers a full-spectrum discussion on drug delivery through carbon-based nanocarriers
    • Explores each carbon-based nanocarrier fundamentally for its drug and gene-delivery-related applications
    • Describes critical discussion on various toxicological effects over the utilization of these nanocarriers
    • Embraces existing as well as novel technologies/methodologies related to the synthesis and functionalization of CBNs, including graphene, graphene oxide, carbon quantum dots, carbon nanotube, fullerene, and smart carbon-based nanocarriers
    This book is aimed at researchers and graduate students in materials and pharmaceutical engineering, including drug delivery systems.
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    Open Access Databases and Datasets for Drug DiscoveryTimely resource discussing the future of data-driven drug discovery and the growing number of open-source databasesWith an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated.The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.Contributed to and edited by experts with long-time experience in the field, Open Access Databases and Datasets for Drug Discovery includes information on:
    • An extensive listing of open access databases and datasets for computer-aided drug design
    • PubChem as a chemical database for drug discovery, DrugBank Online, and bioisosteric replacement for drug discovery supported by the SwissBioisostere database
    • The Protein Data Bank (PDB) and macromolecular structure data supporting computer-aided drug design, and the SWISS-MODEL repository of 3D protein structures and models
    • PDB-REDO in computational aided drug design (CADD), and using Pharos/TCRD for discovering druggable targets
    Unmatched in scope and thoroughly reviewing small and large open data sources relevant for rational drug design, Open Access Databases and Datasets for Drug Discovery is an essential reference for medicinal and pharmaceutical chemists, and any scientists involved in the drug discovery and drug development.
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    This fully updated volume provides an up-to-date and comprehensive overview of the current state of technologies helping to accelerate Alzheimer’s disease drug development. Addressing the latest advances in preclinical and clinical research, including new insights into the molecular mechanisms and emerging therapeutic strategies, the book continues by exploring digital biomarkers and advanced neuroimaging analysis which will transform how clinical trials in the Alzheimer’s disease field are performed. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to greater success in the lab or clinic. Authoritative and practical, Biomarkers for Alzheimer’s Disease Drug Development, Second Edition seeks to inspire and inform future efforts to develop effective treatments for this devastating disease.
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    This third edition volume expands on the previous editions with new and updated discussions on the latest developments in endotoxin contamination, complex physicochemical properties, in vitro immunotoxicity traits, and in vitro drug release properties. Eight chapters in this book are dedicated to physicochemical characterization techniques and cover newer methods such as asymmetric-flow field-flow fractionation, single particle inductively coupled plasma mass spectrometry, and resistive pulse sensing. The next eighteen chapters explore the immunotoxicity of nanomaterials, including microbial contaminants such as endotoxin and beta-glucans, anti-PEG antibodies, autoimmunity, and immunosuppressive properties. The last two chapters talk about new pharmacology protocols, including a new technique to assess drug release and a tissue distribution assay using PEG immunohistochemistry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step instructions to reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Characterization of Nanoparticles Intended for Drug Delivery, Third Edition is a valuable resource that will help both expert and novice researchers further enhance their understanding of this important and developing field.
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    Non-traditional Approaches to Combat Antimicrobial Drug Resistance

    Price range: 550₨ through 1,200₨
    This book provides a detailed overview of the progress and challenges of non-traditional approaches for tackling antimicrobial resistance. The first chapter covers the factors that make microbes more likely to develop multidrug resistance. The book goes on to discuss the antimicrobial properties of propolis, essential oils and other microbial constituents that are used or under investigation to treat multidrug-resistant infections. Additionally, it covers alternative compounds that work as antimicrobial agents, their mechanisms of action, and how they might be utilized in conjunction with conventional drugs to circumvent drug resistance. The book explores the application of phage therapy and recent advancements in phage-based infection control with an emphasis on multidrug-resistant infections and discusses drug repurposing as a strategy to develop new antimicrobial agents efficiently and expeditiously. Additionally, it discusses the uses of nanoparticles in the treatment of infections brought on by multidrug-resistant pathogens and examines the use of different nanotechnology-based approaches to fudge microbial resistance mechanisms. It concludes by reviewing recent studies on microbial quorum-sensing systems and focuses on the significance of quorum-sensing systems in controlling microbial resistance mechanisms and at the same time highlights the importance and role of antimicrobial stewardship program to fight microbial infections. The book is an invaluable source of knowledge and information for academics, basic and clinical researchers, clinicians, and paramedic staff involved in one way or the other in the development and use of antimicrobial agents and strategies to combat multidrug resistance.​
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    Tubercular Drug Delivery Systems: Advances in Treatment of Infectious Diseases

    Price range: 550₨ through 1,200₨
    The book targets new advances in areas of treatment and drug delivery sciences for tuberculosis.  It covers advances in drug therapy and drug targeting that focus on innovative trend defining technologies and drug delivery platforms in the understanding of host-pathogens relationship for providing better therapy.  A wide variety of novel and nano-formulations using promising technologies are being explored to deliver the drug via different administration routes. This book It addresses the gap between new approaches and old treatment modalities and how they are superior in pharmacological performance when tested in in-vitro and in-vivo. Audience from wide range group like from researchers to regulatory bodies can benefit from the compiled information to find out patient needs and current research advances in the field of tuberculosis research.
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    Patriarchal Precedents: Sexuality and Social Relations (Routledge Revivals)

    Price range: 550₨ through 1,250₨
    First published in 1983, Patriarchal Precedents is an excavation of the term patriarchy. Rosalind Coward shoes how the debates about patriarchy and matriarchy were crucial to social theories in the nineteenth century, discussing how the resolution of these debates resulted in our present ways of (mis)understanding the family, sexual relations and sexual characteristics. Rosalind Coward argues that the violent debates around patriarchy tell a salutary tale about how the term presupposed as much as it set out to explain. She demonstrates how it was used in Marxism and psychoanalysis in ways which blocked any radical thinking about sexual relations, and how the arguments against the term patriarchy within anthropology still have to be taken seriously. She argues that in order to advance our understanding of how power is exercised in sexual relations, of the place which sexual relations have within society and the construction of sexual characteristics, a series of presuppositions about sexual relations must now be cleared away. This book will be of interest to students of gender studies, women's studies, sexuality, men' s studies, sociology and anthropology.
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    New materials and manufacturing techniques are emerging with potential to address the challenges associated with the manufacture of pharmaceutical systems that will teach new tricks to old drugs. 3D printing (3DP) is a technique that can used for the manufacturing of dosage forms, and especially targeting paediatric and geriatric formulations, as permits the fabrication of high degrees of complexity with great reproducibility, in a fast and cost-effective fashion, and offers a new paradigm for the direct manufacture of personalized dosage forms. The book is covering the basics behind each additive manufacturing (AM) method, current applications in pharmaceutics for each 3DP method, and case studies (examples) from a teaching perspective, targeting undergraduate (UG) and postgraduate (PG) students. A unique to this book is the integration of studies based upon the use of different AM technologies, which designed to reinforce importance printing parameters and material considerations. The book includes case studies or multiple-choice questions (MCQs), which allow application of the content in a flipped-classroom.
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    Genome Editing in Drug Discovery 1st Edition

    Price range: 550₨ through 1,200₨
    GENOME EDITING IN DRUG DISCOVERYA practical guide for researchers and professionals applying genome editing techniques to drug discoveryIn Genome Editing in Drug Discovery, a team of distinguished biologists delivers a comprehensive exploration of genome editing in the drug discovery process, with coverage of the technology’s history, current issues and techniques, and future perspectives and research directions. The book discusses techniques for disease modeling, target identification with CRISPR, safety studies, therapeutic editing, and intellectual property issues.The safety and efficacy of drugs and new target discovery, as well as next-generation therapeutics are also presented.Offering practical suggestions for practitioners and academicians involved in drug discovery, Genome Editing in Drug Discovery is a fulsome treatment of a technology that has become part of nearly every early step in the drug discovery pipeline. Selected contributions also include:
    • A thorough introduction to the applications of CRISPRi and CRISPRa in drug discovery
    • Comprehensive explorations of genome-editing applications in stem cell engineering and regenerative medicine
    • Practical discussions of the safety aspects of genome editing with respect to immunogenicity and the specificity of CRISPR-Cas9 gene editing
    • In-depth examinations of critical socio-economic and bioethical challenges in the CRISPR-Cas9 patent landscape
    Perfect for academic researchers and professionals in the biotech and pharmaceutical industries, Genome Editing in Drug Discovery will also earn a place in the libraries of medicinal chemists, biochemists, and molecular biologists.
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    Benzodiazepine-Based Drug Discovery (Heterocyclic Drug Discovery)

    Price range: 550₨ through 1,250₨
    Benzodiazepine-Based Drug Discovery covers benzodiazepines and benzothiazepines, which constitute two pivotal classes of heterocyclic compounds widely used as core structures of medicinal drugs for the treatment of depression, epilepsy, seizures and muscle spasms. 1,4-Benzodiazepine, 1,5-benzodiazepine, and 1,5-benzothiazepine are the most studied groups of benzodiazepines and benzothiazepines because of their outstanding potential biological activities. This book offers a broad range of recent developments and detailed coverage of the synthesis and biological activities of the drugs based on benzodiazepine and benzothiazepine matrixes, and is an ideal reference guide to researchers working in organic and medicinal chemistry. The importance of these privileged pharmacophores is not limited to the treatment of psychotic disorders because minor changes in the structures can generate various biological activities. They represent a wide range of therapeutic functions such as anticonvulsant, antianxiety, anti-depressant, antiviral, anti-HIV, anti-inflammatory, anticoagulant, anti-obesity, endothelin antagonist, cholecystokinin antagonist, and vasopressin receptor antagonist activities.- Presents detailed coverage of chemical structures and practical synthetic methods of benzodiazepines and benzothiazepines in drug discovery - Compiles detailed in vivo and in vitro biological activity data of 1,4-benzodiazepine- and 1,5-benzodiazepine-based drugs that will help researchers design and develop innovative drugs - Discusses promising avenues and potential challenges in the development of new benzodiazepines and benzothiazepines in medicinal drug synthesis
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    Gene, Drug, and Tissue Engineering (Methods in Molecular Biology Book 2575)

    Price range: 550₨ through 1,250₨
    This book combines discursive chapters that present the latest progress in molecular biology, drug discovery, organ-tissue engineering, and related fields, with a number of descriptive chapters on methods, protocols, and case studies. Structured into four parts, this volume walks the reader through the latest in cellular biology, with discussions on novel medicinal plant metabolites, nanotechnology in precision medicine, nucleic acid-based therapeutics and vaccines, genetic engineering, computational aid, bioinformatics, synthetic organs for transplantation, and organ-tissue engineering. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that ensures quality results in the lab. Authoritative and informative, Gene, Drug, and Tissue Engineering serves as an ideal guide for undergraduate students, postgraduate researchers, and senior researchers working in biomedicine and its underlying technologies, stimulating both computational and experimental development and fostering the exchange of new ideas.
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    Providing a framework for treating substance use disorders (SUDs) in office-based psychotherapy, the second edition of this trusted work has been updated throughout and features two entirely new chapters. The authors show how clinicians from any background can leverage the therapeutic skills they already have to address clients' alcohol and drug problems competently and effectively. Vivid case examples demonstrate ways to engage clients at different stages of change; set collaborative treatment goals; address SUDs concurrently with other psychological problems; and interweave motivational, cognitive-behavioral, and other interventions, tailored to each individual's needs. Reproducible forms and handouts can be downloaded and printed in a convenient 8 1/2" x 11" size.New to This Edition *Chapter on evidence-based principles and interventions. *Chapter on moderation-focused alcohol treatment. *Revised throughout with current data, clinical techniques, and examples. *Reflects over 15 years of important changes in the field--increased demand for integrated treatment, the ongoing opioid crisis, the growth of harm reduction and medication-assisted treatments, and more.
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    Drug Law Enforcement, Policing and Harm Reduction: Ending the Stalemate

    Price range: 550₨ through 1,200₨
    The policing of drugs is an intriguing, complex, and contentious domain that brings into sharp focus the multifaceted nature of the police role and has far-reaching consequences for health, crime, and justice. While research on drugs policing has historically been surprisingly sparse, fragmented, and underdeveloped, the field has recently become a burgeoning area of academic study, influenced by contemporary trends in policing practices, changes in drug policy, and wider social movements. This book makes a much-needed interdisciplinary and international contribution that engages with established and emerging areas of scholarship, advances cutting-edge debates, and sets an agenda for future directions in drugs policing.Drug Law Enforcement, Policing and Harm Reduction is the first edited collection to devote its attention exclusively to drugs policing. It brings together a range of leading scholars to provide a deep and thorough account of the current state of knowledge. In addition to academic analysis, authors also include serving police officers and policymakers, who have influenced how drugs policing is framed and carried out. Together, the contributors draw on a diverse set of empirical studies and theoretical perspectives, with the thread running throughout the book being the concept of harm reduction policing. With accounts from various countries, localities, and contexts, topics covered include the (in)effectiveness and (un)intended consequences of the ‘war on drugs’, attempts to reform drugs policing, and the role of partnerships and policy networks. The broader theme of inequality lies at the heart of this collection.An accessible and compelling read, this book will be of interest to academics and students of criminology, public health, and social policy, especially those researching policing, drug policy, and harm reduction. It also offers valuable insights and practical guidance for professionals working in the drugs field.
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    Computer-Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches outlines the basic theoretical principles, methodologies and applications of different fundamental and advanced CADD approaches and techniques. Including information on current protocols as well as recent developments in the computational methods, tools and techniques used for rational drug design, the book explains the fundamental aspects of CADD, combining this with a practical understanding of the various in silico approaches used in modern drug discovery processes to assess the field in a comprehensive and systematic manner. Providing up-to-date, information and guidance for scientists, researchers, students and teachers, the book helps readers address specific academic and research related problems using illustrative explanations, examples and case studies, which are systematically reviewed.- Highlights in silico approaches to drug design and discovery using computational tools and techniques - Details ligand-based and structure-based drug design in a comprehensive and systematic approach - Summarizes recent developments in computational drug design strategy as novel approaches of rational drug designing
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    This 2-part reference informs readers about the application of drug delivery technologies to herbal medicines. Chapters cover a broad range of major topics on the subject of targeted drug delivery systems. These topics include the application of drug delivery systems for herbal nanomedicines, drug development issues, emerging technologies, adaptations for clinical use, market prospects and challenges of industrial commercialization. Chapters have been contributed by several experts in pharmaceutical chemistry and blend theoretical knowledge with practical aspects of drug delivery.Part I covers the following topics:- Introduction to nanotechnology and herbal-based nanoparticulate systems - Nucleic acid-based therapeutic drug delivery systems - Herbal bioactives: a booster dose for advanced pharmaceutical nanoscience - Pulmonary nano-drug delivery systems - Application of nano-drug delivery systems in improving the therapeutic efficacy of bioactive natural products - PEGylated liposomes - Insulin liposomes - Aquasomes: a promising novel drug carrier - Nanoparticle-aided herbal drugs: therapeutic implications on cholinergic dysfunction with relevance to Alzheimer’s disease - Vitamins based nanomedicine approach - Recent advances in tumor targeting drug delivery systems: fundamentals of advanced pharmaceutical nanoscience - Niosomes: a revolutionary progress in the field of pharmaceutical sciences - Infectious diseases: pharmaceutical nanoscience for targeted drug deliveryThis reference is a valuable resource for scholars that creates awareness of novel drug delivery systems as well as their promising applications in drug targeting, and nanotherapeutics for specific diseases.
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    This 2-part reference informs readers about the application of drug delivery technologies to herbal medicines. Chapters cover a broad range of major topics on the subject of targeted drug delivery systems. These topics include the application of drug delivery systems for herbal nanomedicines, drug development issues, emerging technologies, adaptations for clinical use, market prospects and challenges of industrial commercialization. Chapters have been contributed by several experts in pharmaceutical chemistry and blend theoretical knowledge with practical aspects of drug delivery.Part II covers the following topics:- Pharmaceutical nanosciences and their application in the delivery of various phytoconstituents - Design of cosmeceutical drug delivery systems: the role of nanotechnology in cosmeceuticals - Transfersomes: a novel vesicular transdermal delivery system - Self-nano/micro emulsified drug delivery systems - Phytosomes - The role of nanomedicines in ocular drug delivery systems - Colloidosomes as an efficient novel drug delivery system: an update - Herbal nanoscience: challenges and regulatory perspectives - Vitamins based nanomedicine approach - Dendrimers: a versatile nanoplatform for advanced targeting and bioactive(s) delivery - Targeted drug delivery systems for cells and cell organelles - Liposomes for herbal drug delivery - AI in pharmacy, herbal medicine and drug delivery: sci-fi or reality?This reference is a valuable resource for scholars that creates awareness of novel drug delivery systems as well as their promising applications in drug targeting, and nanotherapeutics for specific diseases.
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    Emerging Applications of Carbon Nanotubes in Drug and Gene Delivery brings together principles behind the formation, characterization and development of carbon nanotubes (CNTs) with recent advances in drug and gene delivery applications. The book begins with an introduction to the unique properties of CNTs, as well as the various synthesis, purification and functionalization methods available. Later chapters cover drug and gene delivery using CNTs for therapeutic applications, comparing advantages and disadvantages of each. The book then goes on to discuss toxicity and safety challenges in using CNTs in biomedicine, with a forward-look at regulatory requirements and clinical translations. This book offers a detailed reference for materials scientists, biomedical engineers, pharmaceutical scientists and geneticists interested in CNTs and nanomedicine.- Provides focused coverage of nanotubes for use in drug and gene delivery applications, offering much-needed detail amongst broader nanomedicine texts - Details the properties, characterization, synthesis, functionalization and applications of CNTs in drug and gene delivery - Discusses toxicity, safety and regulatory aspects of CNTs, with a look towards the clinical translation of CNTs
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    Trying to Make It: The Enterprises, Gangs, and People of the American Drug Trade

    Price range: 550₨ through 1,200₨
    Trying to Make It is R. V. Gundur's journey from the US-Mexico border to America's heartland, from America's prisons to its streets, in search of the true story of the drug trade and the people who participate in it. The book begins in the Paso del Norte area, encompassing the sister cities of Ciudad Juárez and El Paso, which has been in the public eye as calls for securing the border persist. From there, it moves on to Phoenix, which was infamously associated with the drug trade through a series of kidnappings. Finally, the book goes on to Chicago, which has been a lightning rod of criticism for its gangs and violence.Gundur highlights the similarities and differences that exist in the American drug trade within the three sites and how they relate to current drug trade narratives in the US. At each stop, the reader is transported to the city's historical and contemporary contexts of the drug trade and introduced to the individuals who have lived them. Drug retailers, street and prison gang members, wholesalers, and the law enforcement personnel who try to stop them offer readers a comprehensive look at how various illicit enterprises work together to supply the drugs that American users demand.Most importantly, through a combination of macro- and microlevel vantage points, and comparative analysis of three key sites in illicit drug operations, the stories in Trying to Make It remind us that the people involved in the drug trade, for the most part, do not deserve vilification. Far from being a seemingly uniform, widespread threat or an unlimited array of bogeymen and women, they are ordinary people, living ordinary lives, just trying to make it.
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    This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates.The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.
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